Peer-reviewed research, conference presentations, and patent filings underpinning SBC003's scientific foundation.
SunRegen's science is publicly documented. SBC003's mechanism of action, preclinical efficacy, and safety profile have been presented at international ophthalmology conferences and published in peer-reviewed journals. The foundational Aging Cell publication (2022) is open-access and freely available.
Oamen HP, Amos A, Obaniyi J, Obi I, Dong Y, et al.
Aging Cell
SBC003, a rare natural compound, was shown to activate an endogenous neuroprotective response that protects neurons against multiple toxic protein aggregates including amyloid-β, α-synuclein, prion protein, tau, and amylin oligomers. In vivo studies in non-human primates with naturally occurring optic atrophy demonstrated significant RNFL recovery following oral administration.
Dong Y, et al.
Investigative Ophthalmology & Visual Science (IOVS) — ARVO 2020
Dose-dependent neuroprotection of SBC003 was demonstrated in a validated murine model of retinal photoreceptor degeneration. Outer nuclear layer preservation increased significantly at the higher oral dose versus vehicle (p<0.001). OCT imaging confirmed significantly increased neuroretinal thickness across peripheral, mid-peripheral, and central retina.
SunRegen Healthcare AG (applicant)
International patent family — granted in multiple jurisdictions
Patent family covering SBC003 and related compounds for neurodegenerative diseases, degenerative optic and retinal diseases, demyelinating diseases, and neuromuscular disorders. Granted in major global markets.
Pioneering first-in-class orally bioavailable compounds to halt neurodegeneration and restore vision. Clinical-stage. Basel, Switzerland.
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